MDMA (3,4-methylenedioxymethamphetamine), often known as “Ecstasy” or “Molly,” is a synthetic drug that alters mood and perception. It’s known for producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory and time perception. MDMA affects the brain by increasing the activity of neurotransmitters like serotonin, dopamine, and norepinephrine, which are associated with mood, arousal, and energy levels.

1. Dose

• Therapeutic Dosage: In clinical studies, dosages typically range from 75 mg to 125 mg for therapeutic purposes. Doses are calculated based on a patient’s weight and specific needs.
• Avoid High Doses: High doses significantly increase the risk of adverse effects and can lead to neurotoxicity, overheating, and dehydration.

2. Preparation

• Hydration: Drink water but avoid excessive amounts to prevent water intoxication. Around 500 ml per hour is often recommended during active use.
• Rest and Nutrition: A good night’s sleep and a balanced meal prior to use are beneficial.
• Environment: MDMA experiences are usually more positive in calm, supportive, and familiar environments. For therapeutic purposes, this is often a controlled setting with a trained therapist.

3. During Use

• Mindful Use: Avoid mixing MDMA with other drugs or alcohol, as combinations can amplify side effects.
• Hydration and Temperature Control: Take breaks to cool down, especially if in a warm environment or engaging in physical activity.
• Take Breaks: Limiting sessions to avoid frequent use is important, as MDMA impacts serotonin levels, which take time to recover.

4. Post-Use Care

• • Rest and Recovery: Fatigue and emotional sensitivity are common post-use, so ample sleep, a healthy diet, and mild physical activity are beneficial.
  • Hydration and Nutrition: Replenishing electrolytes and eating nutrient-rich foods can aid in recovery.
  • Therapeutic Support: In clinical trials, post-use counseling helps integrate the experience into one’s life positively.

The effects of MDMA generally last between 3 to 6 hours, depending on the dose and individual metabolism. Here’s a breakdown of the typical timeline:

1. Onset (20-60 minutes): After ingestion, users typically start to feel the effects within 20 to 60 minutes. This can begin with feelings of euphoria, warmth, and heightened sensory perception.
2. Peak Effects (1-3 hours): The peak is where the primary effects, like increased energy, empathy, and pleasure, are most intense. This period usually lasts between 1 to 3 hours.
3. Comedown (2-4 hours): The effects gradually fade, and people often feel physically and emotionally drained. Some may feel residual euphoria, while others might experience mild anxiety or sadness.
4. Aftereffects (up to 24 hours): Following the primary effects, some people feel tired or “drained” for the rest of the day or even into the following day.

The total experience from onset to the end of aftereffects can be around 12-24 hours, though the most noticeable effects are generally over within 6 hours.