Ketamine is a classical dissociative substance of the arylcyclohexylamine class. Originally used as a surgical anesthetic but after becoming popular recreationally it is now used for its potential to relieve treatment-resistant depression. Effects of Ketamine are highly dose dependent. Subjective effects submitted by users report Ketamine at lower doses causes alcohol-like disinhibition and relaxing effects. At high doses Ketamine causes effects including motor control loss, hallucinations, memory suppression, dissociation and potentially “out-of-body” experiences.

1. Dose

• Therapeutic Dosage: Nasal spray ketamine is typically given in a specific dose based on the patient’s needs and response, often as one to two sprays per nostril. Sessions are usually scheduled once or twice weekly, depending on therapeutic goals.
• Controlled Administration: The dose is typically pre-measured and adjusted gradually to maintain effectiveness and minimize side effects.

2. Preparation

• Hydration and Nutrition: Patients are encouraged to stay hydrated and avoid heavy meals immediately before the session, as ketamine can sometimes cause mild nausea.
• • Calm Environment: A relaxed, quiet environment in the clinic or treatment center supports a comfortable and therapeutic experience.

3. During Use

• Professional Supervision: Patients remain under observation during the session, with healthcare providers monitoring vital signs and response to ensure safety.
• Minimal Stimulation: Keeping lights dim and avoiding loud sounds helps create a calm atmosphere, allowing the patient to engage fully in the experience.

4. Post-Use Care

• • Rest and Recovery: Patients may feel mild dizziness, fatigue, or sensory sensitivity after the session, so post-session rest and hydration are recommended.
  • Therapeutic Integration: Follow-up sessions with a therapist can help patients process the experience and integrate any insights, enhancing the long-term benefits of the treatment.

The effects of grape-flavored nasal spray ketamine generally last between 45 minutes to 2 hours, depending on the dosage and individual factors. Here’s a timeline:

1. Onset (5-15 minutes): Effects begin quickly due to nasal absorption, with patients typically feeling relaxed and emotionally lighter within minutes. The grape flavor adds comfort during this initial phase.
2. Peak Effects (30-60 minutes): Patients experience enhanced calm, introspection, and mild dissociation, allowing for therapeutic exploration in a more enjoyable manner. The peak is often less intense than with IV or IM ketamine.
3. Comedown (30-60 minutes): The effects gradually diminish, leaving patients feeling centered and often with a lingering sense of calm and emotional relief.
4. Aftereffects (up to 24 hours): Many report feeling emotionally lighter, less burdened, and with improved mood for days to weeks following treatment, depending on their response and therapy structure.