Type S Ketamine, also known as esketamine, is the “S-enantiomer” of ketamine. This specific form has been approved for certain medical uses, including the treatment of treatment-resistant depression and major depressive disorder with acute suicidal ideation. Type S Ketamine is often chosen for its potent antidepressant effects and a somewhat faster onset than traditional racemic ketamine. It is administered primarily in a clinical setting, where its therapeutic benefits can be carefully managed and monitored.

1. Dose

• Therapeutic Dosage: Dosage levels for Type S Ketamine are typically individualized, based on patient needs and response. Administration methods include nasal spray, intravenous (IV), or intramuscular (IM) routes, commonly in a clinical setting.
• Controlled Administration: Type S Ketamine is often dosed at intervals, such as once or twice weekly, to avoid tolerance buildup and monitor effects over time.

2. Preparation

• Hydration and Nutrition: Maintaining hydration and eating a balanced meal prior to the session can improve comfort, as ketamine sometimes causes mild nausea.
• Calm Environment: A relaxed, comfortable clinical setting enhances the therapy experience, reducing the likelihood of anxiety or discomfort.

3. During Use

• Professional Supervision: With Type S Ketamine, professional oversight is crucial, as the experience may involve some dissociative effects. Medical personnel monitor vital signs and response to ensure patient safety.
• Minimal Stimulation: A quiet, low-stimulation environment can help keep patients calm and comfortable as they process the ketamine experience, promoting therapeutic breakthroughs.

4. Post-Use Care

• • Rest and Recovery: Mild fatigue or dizziness can persist post-session, so rest and hydration are recommended. Some patients also report mild mood sensitivity.
  • Therapeutic Integration: Post-session counseling can help patients reflect on and integrate their ketamine experience, maximizing long-term therapeutic benefits.

The effects of Type S Ketamine last between 1 to 2 hours, depending on the dose and administration method. Here’s a breakdown:

1. Onset (5-10 minutes): Effects usually begin within a few minutes (particularly with IV or IM administration), with patients often experiencing mild euphoria, a sense of calm, and reduced anxious thoughts.
2. Peak Effects (30-60 minutes): The peak effect phase may involve a blend of relaxation, dissociation, and introspection. Type S Ketamine is noted for being somewhat gentler in dissociative impact compared to other ketamine forms.
3. Comedown (30-60 minutes): The effects gradually wear off, leaving patients often feeling calm, centered, and reflective as they return to their baseline state.
4. Aftereffects (up to 24 hours): Some report feeling “lighter” emotionally, with reduced depressive symptoms lasting for days to weeks, depending on individual response and therapy structure.